It's an engine.
It needs to be run.
Just like your regular engine that also has the moving parts lubricated, the lubricant runs down, following the law of gravity, leaving the parts not lubricated for the next start.
From
http://www.edmunds.com/ownership/techcenter/articles/46869/article.html
" Second, if you live in a place with a cold climate, it might not make much sense to run the A/C during the winter months, but many shop technicians recommend running your A/C system regularly, because it contains a light mineral oil in the refrigerant to keep the compressor properly lubricated. The general rule of thumb is 10 minutes per month."
I always ran my manual AC for 10 minutes a week.
I haven't had an AC unit go "bad" in many, many years. The last one I can remember was on an 86 Dodge turbo car. It developed a leak and it ran without refrigerant (And obviously without oil) for awhile. Goodbye compressor.
Seems like a pointless argument as it is
A- easy to do
B- Can't hurt
and
C- might help
With the Murano I leave the Auto on all the time.
I paid for an auto system and I am going to use an auto system.
Homer